network control principles in c. elegans
Control is essential to the functioning of any neural system. Indeed, under healthy conditions the brain must be able to continuously control the state of its numerous circuits, maintaining a tight functional control between the system’s inputs and outputs. One may therefore hypothesise that the brain’s wiring is predetermined by the need to maintain control across multiple scales. Recent advances in network control have offered a powerful mathematical framework to explore the structure-function relationship in complex biological, social and technological networks, and are beginning to yield important and precise insights for neuronal systems. The allure of the network control paradigm is the promise of a framework to unite the distinct datasets, and provide mechanistic explanations for observed structure and function.
publications
Synthetic ablations in the C. elegans nervous system
Emma K. Towlson and Albert-László Barabási.Network Neuroscience, 2020, 4 (1): 200–216.
Caenorhabditis elegans and the network control framework - FAQs
Emma K. Towlson, Gang Yan, Petra E. Vértes, Yee Lian Chew, Denise S. Walker, William R. Schafer, and Albert-László Barabási.Phil. Trans. R. Soc. B, 2018, 373(1758):20170372.
Network control principles predict neuron function in the Caenorhabditis elegans connectome
Gang Yan†, Petra E. Vértes†, Emma K. Towlson†, Yee Lian Chew, Denise S. Walker, William R. Schafer, and Albert-László Barabási†These authors contributed equally to this work.
Nature, 2017, 550: 519-523.
Recordings of Caenorhabditis elegans locomotor behaviour following targeted ablation of single motorneurons
Yee Lian Chew, Denise S. Walker, Emma K. Towlson, Petra E. Vértes, Gang Yan, Albert-László Barabási, and William R. SchaferScientific Data, 2017, 4: 170156.
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conference contributions
Synthetic essentiality: Muscle controllability following multiple neuronal ablations in the C. elegans nervous system
Poster at the 22nd International C. elegans Conference, UCLA (2019).Lightning talk and poster at Network Neuroscience satellite, NetSci, University of Vermont Complex Systems Center (2019)
Network control theoretic approaches to understanding brain structure and function
Talk at Biology Department colloquium series, NEU (2019)Introduction to network control: Concepts, methods, and applications to neuroscience
Talk at OHBM, Singapore (2018)Control principles in the Caenorhabditis elegans nervous system
Talk at NetSci, Paris (2018)Talk at Analysis and Interpretation of Connectomes, Janelia Research Campus (2018)
Control principles in the Caenorhabditis elegans nervous system
Talk at Complenet, Northeastern University (2018)Talk at Janelia Research Campus (2016)